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  "author": [
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  "author": [
            
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    "Raths, Johannes",
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    "Raths, Johannes",
            
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    "Schinz, Linda",
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    "Schinz, Linda",
            
5
    "Mangold-D\u00f6ring, Annika",
5
    "Mangold-D\u00f6ring, Annika",
            
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    "Hollender, Juliane"
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    "Hollender, Juliane"
            
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  ],
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  ],
            
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  "author_email": null,
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  "citation_publication": "Raths, J., Schinz, L., Mangold-D\u00f6ring, 
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  "citation_publication": "Raths, J., Schinz, L., Mangold-D\u00f6ring, 
            
10
A., & Hollender, J. (2023). Elimination Resistance: Characterizing 
10
A., & Hollender, J. (2023). Elimination Resistance: Characterizing 
            
11
Multi-compartment Toxicokinetics of the Neonicotinoid Thiacloprid in 
11
Multi-compartment Toxicokinetics of the Neonicotinoid Thiacloprid in 
            
12
the Amphipod Gammarus pulex Using Bioconcentration and 
12
the Amphipod Gammarus pulex Using Bioconcentration and 
            
13
Receptor-Binding Assays. Environmental Science & Technology, 
13
Receptor-Binding Assays. Environmental Science & Technology, 
            
14
57(24), 8890\u20138901. https://doi.org/10.1021/acs.est.3c01891\n",
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57(24), 8890\u20138901. https://doi.org/10.1021/acs.est.3c01891\n",
            
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  "doi": "10.25678/000841",
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  "doi": "10.25678/000841",
            
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  "geographic_name": [
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  "geographic_name": [
            
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    "Bubikon",
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    "Bubikon",
            
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    "D\u00fcbendorf",
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    "D\u00fcbendorf",
            
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    "Switzerland"
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    "Switzerland"
            
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  ],
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  "license_title": null,
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  "license_title": null,
            
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  "maintainer": "Raths, Johannes",
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  "maintainer": "Raths, Johannes",
            
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  "maintainer_email": "Raths, Johannes <johannes.raths@eawag.ch>",
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  "maintainer_email": "Raths, Johannes <johannes.raths@eawag.ch>",
            
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  "metadata_modified": "2025-04-03T09:16:35.830438",
            
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  "name": 
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  "name": 
            
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limination-resistant-characterizing-multi-compartment-toxicokinetics",
35
limination-resistant-characterizing-multi-compartment-toxicokinetics",
            
36
  "notes": "Delayed toxicity is a phenomenon observed for aquatic 
36
  "notes": "Delayed toxicity is a phenomenon observed for aquatic 
            
37
invertebrates exposed to nicotinic acetylcholine receptor (nAChR) 
37
invertebrates exposed to nicotinic acetylcholine receptor (nAChR) 
            
38
agonists such as neonicotinoids. Furthermore, recent studies observed 
38
agonists such as neonicotinoids. Furthermore, recent studies observed 
            
39
an incomplete elimination of neonicotinoids from exposed amphipods. 
39
an incomplete elimination of neonicotinoids from exposed amphipods. 
            
40
However, a mechanistic link between receptor binding and toxicokinetic 
40
However, a mechanistic link between receptor binding and toxicokinetic 
            
41
modeling has not been demonstrated yet.\r\nThe elimination of the 
41
modeling has not been demonstrated yet.\r\nThe elimination of the 
            
42
neonicotinoid thiacloprid in the freshwater amphipod Gammarus pulex 
42
neonicotinoid thiacloprid in the freshwater amphipod Gammarus pulex 
            
43
was studied in several toxicokinetic exposure experiments, 
43
was studied in several toxicokinetic exposure experiments, 
            
44
complemented with in vitro and in vivo receptor binding assays. Based 
44
complemented with in vitro and in vivo receptor binding assays. Based 
            
45
on the results, a two-compartment model was developed to predict 
45
on the results, a two-compartment model was developed to predict 
            
46
uptake and elimination kinetics of thiacloprid in G. pulex.\r\nAn 
46
uptake and elimination kinetics of thiacloprid in G. pulex.\r\nAn 
            
47
incomplete elimination of thiacloprid independent of elimination phase 
47
incomplete elimination of thiacloprid independent of elimination phase 
            
48
duration, exposure concentrations and pulses was observed. 
48
duration, exposure concentrations and pulses was observed. 
            
49
Additionally, the receptor binding assays indicated irreversible 
49
Additionally, the receptor binding assays indicated irreversible 
            
50
binding of thiacloprid to the nAChRs. Accordingly, a 
50
binding of thiacloprid to the nAChRs. Accordingly, a 
            
51
toxicokinetic-receptor model consisting of a structure and a membrane 
51
toxicokinetic-receptor model consisting of a structure and a membrane 
            
52
protein (i.e., nAChR) compartment was developed. The model 
52
protein (i.e., nAChR) compartment was developed. The model 
            
53
successfully predicted internal thiacloprid concentrations across 
53
successfully predicted internal thiacloprid concentrations across 
            
54
various experiments. \r\nOur results help understanding the delayed 
54
various experiments. \r\nOur results help understanding the delayed 
            
55
toxic and receptor-mediated effects towards arthropods caused by 
55
toxic and receptor-mediated effects towards arthropods caused by 
            
56
neonicotinoids. Furthermore, the results suggest that more awareness 
56
neonicotinoids. Furthermore, the results suggest that more awareness 
            
57
towards long-term toxic effects of irreversible receptor binding is 
57
towards long-term toxic effects of irreversible receptor binding is 
            
58
needed in a regulatory context. The developed model supports future 
58
needed in a regulatory context. The developed model supports future 
            
59
toxicokinetic assessment of receptor binding contaminants. \r\n",
59
toxicokinetic assessment of receptor binding contaminants. \r\n",
            
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  "organization": {
            
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    "approval_status": "approved",
            
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    "created": "2019-09-18T14:11:45.483866",
            
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    "description": "We study the presence, fate and behaviour of 
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    "description": "We study the presence, fate and behaviour of 
            
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organic contaminants in natural and treated waters with currently two 
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organic contaminants in natural and treated waters with currently two 
            
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main focuses. First, we improve and apply target and non-target 
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main focuses. First, we improve and apply target and non-target 
            
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analysis using high resolution mass spectrometry to obtain a more 
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analysis using high resolution mass spectrometry to obtain a more 
            
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comprehensive picture of contamination in aquatic environments and to 
70
comprehensive picture of contamination in aquatic environments and to 
            
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characterize natural and technical elimination processes. Secondly, we 
71
characterize natural and technical elimination processes. Secondly, we 
            
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study uptake and biological transformation of contaminants in aquatic 
72
study uptake and biological transformation of contaminants in aquatic 
            
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organisms to better understand the effects on the organisms.",
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organisms to better understand the effects on the organisms.",
            
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  "status": "incomplete",
            
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  "substances": [
            
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    "Thiacloprid 
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    "Thiacloprid 
            
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H9ClN4S/c11-9-2-1-8(5-13-9)6-15-3-4-16-10(15)14-7-12/h1-2,5H,3-4,6H2)"
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    "neonicotinoid"
            
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  ],
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  "systems": [
            
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    "lab",
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    "lab",
            
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    "water",
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    "water",
            
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    "gammarid tissue"
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      "state": "active",
200
      "state": "active",
            
172
      "vocabulary_id": null
201
      "vocabulary_id": null
            
173
    }
202
    }
            
174
  ],
203
  ],
            
175
  "tags_string": 
204
  "tags_string": 
            
176
"bioaccumulation,invertebrates,micropollutants,Organic 
205
"bioaccumulation,invertebrates,micropollutants,Organic 
            
177
contaminants,insecticides",
206
contaminants,insecticides",
            
178
  "taxa": [
207
  "taxa": [
            
179
    "Gammarus pulex"
208
    "Gammarus pulex"
            
180
  ],
209
  ],
            
181
  "taxa_generic": [
210
  "taxa_generic": [
            
182
    "invertebrates",
211
    "invertebrates",
            
183
    "crustaceans",
212
    "crustaceans",
            
184
    "amphipods",
213
    "amphipods",
            
185
    "gammarids"
214
    "gammarids"
            
186
  ],
215
  ],
            
187
  "timerange": [
216
  "timerange": [
            
188
    "2021-10 TO 2022-10"
217
    "2021-10 TO 2022-10"
            
189
  ],
218
  ],
            
190
  "title": "Data for: Elimination resistant: Characterizing 
219
  "title": "Data for: Elimination resistant: Characterizing 
            
191
multi-compartment toxicokinetics of the neonicotinoid thiacloprid in 
220
multi-compartment toxicokinetics of the neonicotinoid thiacloprid in 
            
192
the amphipod Gammarus pulex using bioconcentration and receptor 
221
the amphipod Gammarus pulex using bioconcentration and receptor 
            
193
binding assays",
222
binding assays",
            
194
  "type": "dataset",
223
  "type": "dataset",
            
195
  "url": "https://doi.org/10.25678/000841/",
224
  "url": "https://doi.org/10.25678/000841/",
            
196
  "variables": [
225
  "variables": [
            
197
    "concentration"
226
    "concentration"
            
198
  ],
227
  ],
            
199
  "version": null
228
  "version": null
            
200
}
229
}